Plume Clinic is a Denver-based telehealth company built for and largely by the transgender community, offering gender-affirming hormone therapy, everyday medical care, medical letters of support, and community programming entirely through a phone. Founded in 2019 by physicians Dr. Jerrica Kirkley and Dr. Matthew Wetschler, Plume has served over 50,000 trans and gender non-conforming people across nearly every U.S. state, positioning itself as the first and largest health-tech company designed specifically for trans lives.
Pandia Health is a doctor-founded, women-led telehealth company that prescribes and delivers birth control, acne treatment, and menopause hormone therapy across the United States. Founded in 2016 by Stanford-affiliated physician Dr. Sophia Yen and a team of clinicians and operators, the company built its business on a simple bet: most American women still struggle to get continuous access to hormonal medication, and a recurring, mail-order subscription paired with a board-certified physician network can fix it.
Joanna Strober is the co-founder and CEO of Midi Health, the first menopause startup to achieve unicorn status, raising $100M in Series D funding in February 2026 at a $1B+ valuation. A former Bessemer Venture Partners general partner and Sterling Stamos managing director turned entrepreneur, she built Midi Health after her own year-long struggle to get a perimenopause diagnosis in her late 40s. Midi now serves 230,000+ patients across all 50 states through a network of 500+ clinicians, with care covered by approximately 80% of PPOs. Named to TIME100 Health 2025, CNBC Changemakers 2025, and Forbes 50 Over 50 2023, Strober is also a published author (Getting to 50/50) and a former founder of Kurbo Health, the first digital therapeutic for childhood obesity, which she sold to WW.