GeneCentric Therapeutics is a Durham, North Carolina precision-oncology company that reads cancer's gene activity, not just its mutations, from a tube of blood. Its proprietary EXpressCT technology infers RNA-based gene expression signatures from cell-free DNA fragmentomics, and its GenomicsNext platform combines that expression read-out with DNA variant detection in a single liquid biopsy. The company also markets PurIST, an RNA expression subtyping test for pancreatic cancer. Founded in 2011 out of gene-expression research at UNC, GeneCentric partners with biopharma and commercial labs to bring richer, blood-based biomarkers into routine cancer care.
Michael V. Milburn is the CEO and President of GeneCentric Therapeutics, a Durham, North Carolina biotech building RNA-based liquid biopsy tools that read a tumor's behavior from a single tube of blood. A structural biologist by training, he helped solve the first crystal structures of the Ras cancer protein at Berkeley in the late 1980s, then spent decades building research engines at Sirtris, Plexxikon, and Metabolon before taking the top job at GeneCentric in 2019. His current bet: that the fragments of DNA shed by tumors carry enough information to infer gene expression, not just mutations, turning a blood draw into a near-complete molecular portrait of cancer.