epigenome-editing
(2)
Tune Therapeutics
Tune Therapeutics is a genetic-medicine company building tools to turn genes up or down without cutting DNA. Its TEMPO epigenetic-editing platform tunes gene expression the way a sound engineer rides a fader - reversible, programmable, and precise. Spun out of Duke's Gersbach Lab, Tune raised over $175M in Series B financing in January 2025 and is running first-in-human trials of TUNE-401, an epigenetic silencer for chronic hepatitis B, with the larger ambition of editing the genome's software to extend human healthspan.
John McHutchison
John McHutchison, AO, MD is the CEO and Chairman of Tune Therapeutics, a pioneering epigenome editing company based in Durham, NC. An internationally acclaimed hepatologist and drug developer, McHutchison spent nearly a decade at Gilead Sciences as Chief Scientific Officer, where he led the development of transformative hepatitis C cures used by over 3.2 million people worldwide, including Sovaldi and Harvoni. Now at Tune, he is steering the company's TEMPO epigenome editing platform toward a new era of precision medicine for chronic and complex diseases.