dna-mismatch-repair
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Michael Shih
Michael Shih is the Chief Executive Officer of NeoPhore Ltd, a London-based small molecule neoantigen immuno-oncology company developing first-in-class drugs that target the DNA mismatch repair (MMR) pathway to make cancers more visible to the immune system. An attorney by training with degrees in biology, he spent nearly two decades structuring biotech deals before sitting in the chief executive's chair, with senior business development and corporate development roles at Kite Pharma, Biogen, Sanofi, Epizyme, Forest Laboratories, Kastle Therapeutics and Eisai. He took the helm at NeoPhore in December 2024, right after the company closed an oversubscribed Series B round backed by Bristol Myers Squibb.
NeoPhore Ltd
NeoPhore is a UK small-molecule immuno-oncology company developing first-in-class inhibitors of the DNA mismatch repair (MMR) pathway. By temporarily switching off MMR, its drugs are designed to make tumours generate fresh neoantigens, become visible to the immune system, and respond to checkpoint immunotherapy - extending the benefit of drugs like Keytruda to patients whose cancers are otherwise immune-cold. A 2017 spin-out of Cambridge's PhoreMost, NeoPhore has raised roughly $47M and counts Bristol Myers Squibb and Memorial Sloan Kettering among its backers and collaborators.