deep-brain-stimulation
(5)
AiM Medical Robotics
AiM Medical Robotics is a Worcester, Massachusetts medical device company building a portable, MRI-compatible surgical robot that lets neurosurgeons operate under continuous, real-time MRI guidance. Spun out of Gregory Fischer's Automation and Interventional Medicine (AIM) lab at Worcester Polytechnic Institute, the platform aims to make procedures such as deep brain stimulation lead placement, biopsy, tumor ablation and targeted drug delivery faster, more precise and less variable - reducing procedure time by up to 50% and expanding access to advanced neurosurgical care.
Enspire DBS Therapy, Inc.
Enspire DBS Therapy is a Cleveland-based, clinical-stage medical device company commercializing deep brain stimulation (DBS) paired with physical rehabilitation to restore arm and hand function in people living with chronic impairment after a stroke. Spun out of Cleveland Clinic in 2010, the company builds on more than a decade of research targeting the brain's dentate nucleus to re-establish neurological input during rehab. Its DBS-plus-rehab approach showed encouraging results in the first-in-human EDEN trial published in Nature Medicine, and Enspire is now running RESTORE, a multicenter pivotal study aimed at FDA marketing authorization.
Nudge
Nudge is a San Francisco neurotechnology company building non-invasive, whole-brain interfaces powered by focused ultrasound. Founded in 2024 by Coinbase co-founder Fred Ehrsam alongside Jeremy Barenholtz and Quintin Frerichs, the company aims to stimulate and image deep brain circuits with millimeter precision - no surgery required. Its first human-ready system, Nudge Zero, is being used in research studies today, with a long-term goal of a headphone-like consumer device that lets people shift their brain state - sleep, focus, mood, habits - at the press of a button. Nudge raised a $100M Series A in July 2025 led by Thrive Capital and Greenoaks.
Attune Neurosciences, Inc.
Attune Neurosciences is a San Francisco-based, clinical-stage medical device company building what it calls the first wearable, non-invasive focused-ultrasound system for deep brain therapy. Its investigational headband, ATTN201, uses low-intensity transcranial focused ultrasound (tFUS) to reach precise deep-brain targets - like the central medial thalamus - while recording EEG and head movement, aiming to treat sleep and wake disorders, depression, addiction recovery, and other neurological and psychiatric conditions without drugs or surgery.
NeuroBionics
NeuroBionics is a Boston-area neurotechnology company spun out of more than a decade of MIT research. It builds hair-thin, flexible bioelectronic fibers that reach neural targets through the body's blood vessels instead of open surgery. Its lead device, evStim, aims to deliver deep brain and peripheral nerve stimulation endovascularly, potentially widening access to neuromodulation therapy for conditions like Parkinson's disease, epilepsy, chronic pain, and depression.