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CairnSurgical, Inc.
CairnSurgical is a clinical-stage medical device company in Lebanon, New Hampshire, building patient-specific surgical guidance for breast cancer lumpectomy. Its Breast Cancer Locator (BCL) System pairs a 3D-printed, bra-like form molded to each patient's anatomy with an interactive 3D Visualizer derived from supine MRI, giving surgeons a precise blueprint of a tumor's size, shape, depth and edges. The goal is to cut the 20 to 25 percent re-excision rate in breast-conserving surgery toward zero. Spun out of Dartmouth College and Dartmouth-Hitchcock Medical Center in 2015, the company reported 94 percent margin-negative resections in a European study and filed for FDA De Novo clearance in 2026.
Terragia Biofuel
Terragia Biofuel is a New Hampshire climate-tech startup turning non-food plant waste into cost-competitive, low-carbon ethanol using engineered thermophilic bacteria. Its consolidated bioprocessing (CBP) approach skips the expensive enzymes and thermochemical pretreatment that have historically sunk cellulosic biofuel economics, promising an 8x shorter payback period at 10x smaller scale. Spun out of Professor Lee Lynd's decades of research at Dartmouth, Terragia aims to make biofuels for hard-to-electrify transport - aviation, shipping, and long-haul trucking - that can actually compete with fossil fuels.