clinical-stage-medtech
(2)
Axon Therapies, Inc.
Axon Therapies is a clinical-stage medical device company developing SAVM (Splanchnic Ablation for Volume Management), a minimally invasive, implant-free catheter procedure that ablates the greater splanchnic nerve to calm an overactive sympathetic nervous system and rebalance blood volume in patients with heart failure - particularly heart failure with preserved ejection fraction (HFpEF). Incubated by the medtech studio Coridea and backed by leading healthcare investors, the company is advancing its Satera Ablation System through randomized, sham-controlled feasibility trials.
Enspire DBS Therapy, Inc.
Enspire DBS Therapy is a Cleveland-based, clinical-stage medical device company commercializing deep brain stimulation (DBS) paired with physical rehabilitation to restore arm and hand function in people living with chronic impairment after a stroke. Spun out of Cleveland Clinic in 2010, the company builds on more than a decade of research targeting the brain's dentate nucleus to re-establish neurological input during rehab. Its DBS-plus-rehab approach showed encouraging results in the first-in-human EDEN trial published in Nature Medicine, and Enspire is now running RESTORE, a multicenter pivotal study aimed at FDA marketing authorization.