caltech-spinout
(5)
Indi Molecular
Indi Molecular is a Culver City, California biotech developing a synthetic alternative to antibodies called Protein Catalyzed Capture (PCC) agents - small, stable cyclic peptides built with click chemistry that bind protein targets with antibody-like specificity while behaving like small-molecule drugs. Spun out of Caltech chemist James Heath's lab in 2013, the company applies its platform to targeted oncology therapeutics and PET imaging agents, aiming to reach targets long considered undruggable, including KRAS G12D pancreatic cancer and ovarian cancer.
Aralez Bio
Aralez Bio is a Berkeley, California biotechnology company that uses engineered enzymes and directed evolution to manufacture noncanonical amino acids (ncAAs) - the specialized building blocks used in peptide drugs and other pharmaceuticals. Spun out of Nobel Laureate Frances Arnold's Caltech lab in 2019, the company runs biocatalytic reactions that produce enantiopure ncAAs in a single step with water as the main byproduct, expanding the amino acid toolbox roughly 1,000-fold. Aralez sells a catalog of thousands of exclusive amino acids and offers custom synthesis and ton-scale production for pharmaceutical customers, including partners among the world's largest drug companies.
Aizen Therapeutics
Aizen Therapeutics is a San Diego, AI-driven biotech spun out of Caltech that designs Mirror Peptides - synthetic drugs built entirely from D-amino acids, the mirror image of the L-amino acids that make up natural proteins. Its DaX platform pairs generative AI with structural biology to design these molecules from scratch, aiming for drugs with the potency of biologics but greater stability, lower immunogenicity, and the potential to be taken orally. The company emerged from stealth in November 2024 with a $13M seed round.
BeyondAI
BeyondAI (formerly Beyond Limits) is an industrial and enterprise AI company born from technology developed at Caltech's NASA Jet Propulsion Laboratory. Founded in 2014, it builds hybrid, neuro-symbolic AI that pairs machine learning and generative AI with rule-based reasoning to deliver explainable, human-like decisions in high-stakes sectors such as energy, oil and gas, manufacturing, utilities and healthcare. Backed by investors including Group 42 and bp ventures, the company raised a $133M Series C in 2020 and rebranded to BeyondAI at LNG2026.
Fluid Efficiency
Fluid Efficiency is a Caltech spin-out that builds MegaSupraMolecules (MSMs), self-assembling polymers that change how fluids move. Its flagship product is a removable drag-reducing agent for natural gas liquids (NGL) pipelines - a fluid class where conventional drag reducers can't be used because leftover polymer fouls downstream fractionation equipment. By letting the additive be removed before sensitive processing, Fluid Efficiency helps midstream operators push more volume through existing pipelines without building new ones. The same polymer platform also reduces fuel misting (and the explosion risk that comes with it), improves lubricant viscosity, and aids long-distance pumping of crude and refined products.