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nassim usman1 totus medicines1 biotech ceo1 covalent inhibitors1 pi3k inhibitor1 dna-encoded library1 omnidel1 small molecule drug discovery1 undruggable targets1 ai drug design1 rna therapeutics1 ribozymes1 catalyst biosciences1 sirna therapeutics1

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Nassim Usman is an organic chemist turned biotech operator who runs Totus Medicines, an Emeryville, California company using a DNA-encoded covalent library platform (OmniDEL) paired with machine learning to build small-molecule drugs against targets long considered undruggable. He took the CEO chair in December 2023 alongside a $66 million Series B, and its lead drug, TOS-358, is the first covalent PI3K-alpha inhibitor in the clinic. Over three decades he has moved from bench chemistry on RNA and ribozymes to the top jobs at Sirna Therapeutics, Catalyst Biosciences, and Principia Biopharma, plus a stint as a venture investor at Morgenthaler Ventures.

nassim usmantotus medicinesbiotech ceocovalent inhibitorspi3k inhibitortos-358