therapeutic-antibodies
(4)
Suchul Jang
He spent a decade engineering tiny vesicles to smuggle drugs where they were needed. Now he is running the American arm of a Korean biotech that wants the brain to clean up after itself - quietly, without the inflammation that has shadowed Alzheimer's drugs for years.
Antiverse
Antiverse is a UK-based AI-driven biotech that designs functional therapeutic antibodies against targets long considered 'undruggable' - notably G-protein coupled receptors (GPCRs), ion channels, and other transmembrane proteins where conventional antibody discovery routinely fails. Its platform pairs generative AI models, trained for years on the hardest antibody targets, with a proprietary 'lab-in-the-loop' wet lab using engineered cell lines and deep sequencing, taking a target to an optimized antibody in roughly four months. Founded in 2017 and headquartered in Cardiff, Wales, the company works through pharma partnerships and licensing (e.g. Nxera Pharma) alongside its own internal pipeline and non-profit collaborations such as the Cystic Fibrosis Foundation.
Kira Biotech Pty Ltd
Kira Biotech is a Brisbane-based clinical-stage immunology company developing first-in-class antibody therapeutics that retrain the immune system instead of broadly suppressing it. Its lead candidate, KB312, selectively depletes activated immune cells to restore immune tolerance, aiming to treat difficult autoimmune and inflammatory conditions such as rheumatoid arthritis, lupus, type 1 diabetes, and graft-versus-host disease. Built on decades of dendritic-cell research from Australian institutes and led by US rheumatologist Dr Dan Baker, the company launched with a A$20 million Series A in 2019 led by OneVentures and IP Group.
Nabla Bio
Nabla Bio is a Cambridge, Massachusetts biotech building AI plus wet-lab technology to design antibodies and protein therapeutics from scratch. Its Joint Atomic Modeling (JAM) platform generates de novo binders against historically undruggable membrane proteins like GPCRs, and the company has signed collaborations with AstraZeneca, Bristol Myers Squibb, and Takeda worth over a billion dollars in potential payments.