stroke-recovery
(3)
Enspire DBS Therapy, Inc.
Enspire DBS Therapy is a Cleveland-based, clinical-stage medical device company commercializing deep brain stimulation (DBS) paired with physical rehabilitation to restore arm and hand function in people living with chronic impairment after a stroke. Spun out of Cleveland Clinic in 2010, the company builds on more than a decade of research targeting the brain's dentate nucleus to re-establish neurological input during rehab. Its DBS-plus-rehab approach showed encouraging results in the first-in-human EDEN trial published in Nature Medicine, and Enspire is now running RESTORE, a multicenter pivotal study aimed at FDA marketing authorization.
Constant Therapy
Constant Therapy is a Boston-area digital health company that turns speech, language, and cognitive rehabilitation into an AI-personalized app. Spun out of Boston University's Aphasia Research Laboratory in 2012, its platform delivers more than 100,000 evidence-based exercises across 80-plus task categories to people recovering from stroke, traumatic brain injury, aphasia, dementia, and other neurological conditions - and to the clinicians who treat them. A patented NeuroPerformance Engine adapts each session to the individual, extending therapy beyond the clinic and into daily home practice.
REEV
REEV is a medical robotics company building AI-powered wearable robotics to restore everyday mobility for people with neurological gait disorders after stroke, multiple sclerosis or paraplegia. Its flagship DREEVEN is a lightweight (about 3kg) motorized knee orthosis driven by electro-hydraulic actuation and real-time gait sensing, paired with REEV SENSE, an IMU wearable that turns a person's walking pattern into clinical-grade gait reports. Founded in 2021 and split between Boston and Toulouse, REEV raised $9.2M in February 2025 to finalize DREEVEN, run a clinical study at Boston University and prepare for FDA trials.