rwe
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Frekil
Frekil is an AI-powered real-world evidence (RWE) platform for life sciences that turns raw clinical data - EHR, claims, and registries - into regulatory-grade evidence in minutes instead of months. Its agentic pipeline runs the full study lifecycle, from literature review and cohort building through statistical analysis plan generation and final reports, while keeping clinical data isolated from AI models. Founded in 2025 by IIT Bombay alumni Nikhil Tiwari and Shivesh Gupta, Frekil is a Y Combinator (X25/P25) company serving pharma, biotech, CROs, and academic researchers.
Castor
Castor is a health-technology company that builds a cloud-based eClinical platform for running clinical trials - from electronic data capture (EDC) and eConsent to eCOA/ePRO and real-world evidence. Founded in 2012 in Amsterdam by physician-researcher Dr. Derk Arts, Castor set out to replace clunky, expensive trial software with a self-service, researcher-friendly system. Today it supports more than 15,000 studies across 90+ countries and is used by leading CROs and biopharma companies, while pushing decentralized trials and practical AI (Castor Catalyst, built with Google Cloud) into mainstream research.
Century Health
Century Health is a New York-based health technology company that turns fragmented, messy electronic health record data into clean, structured, analysis-ready real-world evidence. Its AI-powered platform, CHARM (Century Health Abstraction & Retrieval Model), automates the curation, abstraction, and de-identification of clinical data to build disease-specific patient registries for pharmaceutical and life sciences research. Founded in 2023 by Vish Srivastava and Sanjay Hariharan, the company reports 97% accuracy against clinical expert judgment and raised a $5M seed round in 2026 led by Origin Ventures.
Verantos
Verantos is a Menlo Park healthcare technology company that turns messy, fragmented patient records - including the clinical notes most platforms ignore - into research-grade real-world evidence (RWE) at scale. Using AI applied to the complete patient record and a rigorous focus on measured accuracy, completeness, and traceability, Verantos helps pharmaceutical companies, regulators, and health systems generate evidence that can hold up to FDA-grade scrutiny across every therapeutic area.
ConcertAI
ConcertAI is a Cambridge, Massachusetts company that combines real-world clinical, genomic, imaging, and claims data with applied AI to accelerate cancer research and clinical development. Through its CARA AI platform, large independent oncology data network, and Digital Trial Solutions, it helps biopharma companies, healthcare providers, and medical societies design smarter trials, match patients faster, and generate evidence on how treatments perform outside controlled studies.
HealthVerity
HealthVerity is a Philadelphia-based healthcare data technology company that runs what it calls the nation's largest privacy-protected healthcare and consumer data ecosystem. Through its Marketplace and a framework it brands IPGE (Identity, Privacy, Governance, Exchange), it lets pharmaceutical companies, payers, and government agencies discover, license, link, and synchronize de-identified data on more than 340 million U.S. individuals to build longitudinal patient journeys and generate real-world evidence - all in a HIPAA-compliant manner.
Andrew Kress
Andrew Kress is the co-founder and CEO of HealthVerity, the Philadelphia company that built one of the largest real-world healthcare data ecosystems and the technology to link, govern and exchange it without exposing patient identities. An English major from Yale who spent his career inside the plumbing of healthcare data - running SDI Health, then leading Healthcare Value Solutions at IMS Health - he started HealthVerity in 2014 to make fragmented, privacy-bound health data usable. The company raised $100M in Series D funding in 2021 led by Durable Capital Partners. Kress also serves on the boards of Philadelphia cultural institutions including the Pennsylvania Academy of the Fine Arts.
Dan Riskin
Dan Riskin is a physician-entrepreneur, trauma surgeon, and healthcare AI executive who founded Verantos in 2015 to generate high-validity real-world evidence from messy clinical data. A serial innovator who began coding at age 5 and sold software at 12, Riskin holds an MD from Boston University and an MBA from MIT, is board-certified in four specialties, and serves as Clinical Professor of Surgery at Stanford. His prior company Health Fidelity was acquired for more than $150 million. Today, Verantos powers regulatory and reimbursement decisions for major pharmaceutical companies by turning fragmented EHR data into research-grade evidence at scale.