Colossal Biosciences is a Dallas-based genetic engineering company using de-extinction science - ancient DNA, CRISPR gene editing, and reproductive technology - to revive lost species like the woolly mammoth, thylacine, dodo, and dire wolf, and to apply the same tools to protecting endangered wildlife. Co-founded in 2021 by tech entrepreneur Ben Lamm and Harvard geneticist George Church, it became Texas' first decacorn with a $10.2 billion valuation and has spun out companies in computational biology and plastic degradation.

Noor Siddiqui is the founder and CEO of Orchid Health, a San Francisco-based biotech startup offering whole-genome sequencing for IVF embryos, screening for 1,200+ genetic variants. Motivated by watching her mother lose her sight to retinitis pigmentosa, she dropped out of high school at 17 to become one of the youngest Thiel Fellows, later returned to earn dual CS degrees at Stanford, and then built Orchid with $16.5M in funding from investors including 23andMe founder Anne Wojcicki and Coinbase's Brian Armstrong. She is also the host of the podcast 'Conceivable with Noor.'