qpcr
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Spear Bio
Spear Bio is a Woburn, Massachusetts biotechnology company commercializing SPEAR (Successive Proximity Extension Amplification Reaction), an ultra-sensitive, wash-free immunoassay platform licensed from Harvard's Wyss Institute. SPEAR measures protein biomarkers at attomolar levels from sub-microliter samples using a two-factor authentication mechanism and standard qPCR instruments, delivering more than a 5-log improvement over conventional ELISA. The company sells assay kits - initially for neurodegeneration biomarkers such as pTau217, pTau231, GFAP and neurofilament light - to academic, pharmaceutical and clinical researchers.
Algorithmic Biologics
Algorithmic Biologics is a Bengaluru- and Delaware-based deep-tech company that treats molecular testing as an information-processing problem. Founded by molecular-computing researcher Dr. Manoj Gopalkrishnan, its patented Tapestry platform uses compressed sensing and combinatorial pooling to run large-scale DNA/RNA/protein tests with far fewer reactions - screening many samples at once and only zooming in where a signal exists. The approach first proved itself as an award-winning, regulator-approved COVID-19 pooling solution and now targets affordable genomics, multiplexed diagnostics, and accelerated assay design.