protein-detection
(2)
Spear Bio
Spear Bio is a Woburn, Massachusetts biotechnology company commercializing SPEAR (Successive Proximity Extension Amplification Reaction), an ultra-sensitive, wash-free immunoassay platform licensed from Harvard's Wyss Institute. SPEAR measures protein biomarkers at attomolar levels from sub-microliter samples using a two-factor authentication mechanism and standard qPCR instruments, delivering more than a 5-log improvement over conventional ELISA. The company sells assay kits - initially for neurodegeneration biomarkers such as pTau217, pTau231, GFAP and neurofilament light - to academic, pharmaceutical and clinical researchers.
Feng Xuan
Feng Xuan is a Boston-based scientist-entrepreneur and the co-founder and CEO of Spear Bio, a biotechnology company building ultra-sensitive immunoassays for protein research and early disease diagnostics. He invented the company's core SPEAR (Successive Proximity Extension Amplification Reaction) technology as a Technology Development Fellow at Harvard's Wyss Institute, translating a decade of research in molecular and immuno-diagnostics into a platform that can measure minute quantities of protein biomarkers from sub-microliter samples. Under his leadership, Spear Bio raised an oversubscribed $45 million Series A in 2024 and earned FDA Breakthrough Device Designation for a blood-based pTau 217 test aimed at early Alzheimer's disease detection.