precision-immunology
(3)
Merida Biosciences
Merida Biosciences is a Cambridge, Massachusetts biotechnology company developing a new class of engineered Fc biotherapeutics that selectively bind and eliminate the disease-causing antibodies behind autoimmune and allergic diseases, while sparing the protective antibodies the immune system needs. Launched publicly in April 2025 with a $121 million Series A, the company aims to treat conditions such as Graves' disease, IgE-mediated allergy and primary membranous nephropathy by clearing pathogenic antibodies and suppressing the B cells that make them - without the broad immunosuppression that limits many existing therapies.
Marengo Therapeutics
Marengo Therapeutics is a Cambridge, Massachusetts clinical-stage biotech reprogramming the immune system from the inside out. Instead of releasing the brakes on T cells the way checkpoint inhibitors do, Marengo's STAR (Selective T Cell Activation Repertoire) platform builds antibody-fusion molecules that target variable regions of the T cell receptor (Vβ) to selectively wake up the specific subsets of T cells that can attack tumors - and remember them. Launched in 2021 with $80M from Apple Tree Partners, its lead drug invikafusp alfa (STAR0602) is in Phase 1/2 trials, has earned FDA Fast Track designation, and is being studied across cancers that no longer respond to PD-1 therapy.
GlycoEra AG
GlycoEra AG is a Swiss-American clinical-stage biotech building a new class of precision medicines that selectively degrade the circulating proteins driving autoimmune disease. Spun out of LimmaTech Biologics in 2021 and powered by a proprietary glycoengineering platform, the company designs bifunctional biologics (G-LyTACs) that pull pathogenic autoantibodies out of the bloodstream with speed and depth - without the broad immune suppression of existing therapies. Its lead program, GE8820, targets pathogenic IgG4 autoantibodies. Backed by $179M across Series A and an oversubscribed $130M Series B, GlycoEra operates from Wädenswil, Switzerland and Newton, Massachusetts.