osteoarthritis
(2)
Pacira BioSciences, Inc.
Pacira BioSciences (Nasdaq: PCRX) is a U.S. biopharmaceutical company built around a single, stubborn idea: surgery and chronic pain should not require a bottle of opioids. Its flagship product, EXPAREL, a long-acting local anesthetic built on the proprietary DepoFoam multivesicular-liposome delivery platform, anchors a portfolio that also includes the ZILRETTA knee-osteoarthritis injection and the iovera handheld cryoanalgesia device. With roughly 790 employees and about $726 million in 2025 revenue, Pacira is pushing beyond established analgesics into gene therapy (PCRX-201) under a '5x30' growth strategy aimed at reinventing how the world treats pain.
Roam Robotics
Roam Robotics builds lightweight, air-powered wearable exoskeletons that augment human strength, endurance and mobility. Founded by Ekso Bionics veteran Dr. Tim Swift, the San Francisco company replaced the heavy metal of traditional exoskeletons with plastic, fabric and pneumatic actuators - making robotic assistance cheap and light enough to wear all day. Its products span consumer skiing (Elevate), medical knee osteoarthritis relief (Ascend), and military performance (Forge), with clinical data showing 46% average knee-pain reduction and up to 2x strength and endurance gains.