
For more than a decade, the Orbus co-founder helped carry one drug through financing, patents and a 343-patient trial. Then a new tumor classification changed the question - and the company’s next chapter.
A tiny Palo Alto biotech took an old molecule into a global Phase 3 trial. The broad result failed, but a new molecular map of brain cancer revealed where the drug may actually work - and offered a playbook for anyone building in a market whose definitions move mid-experiment.