neurorehabilitation
(3)
Enspire DBS Therapy, Inc.
Enspire DBS Therapy is a Cleveland-based, clinical-stage medical device company commercializing deep brain stimulation (DBS) paired with physical rehabilitation to restore arm and hand function in people living with chronic impairment after a stroke. Spun out of Cleveland Clinic in 2010, the company builds on more than a decade of research targeting the brain's dentate nucleus to re-establish neurological input during rehab. Its DBS-plus-rehab approach showed encouraging results in the first-in-human EDEN trial published in Nature Medicine, and Enspire is now running RESTORE, a multicenter pivotal study aimed at FDA marketing authorization.
Wandercraft
Wandercraft is a French robotics company that builds self-balancing walking exoskeletons and, more recently, industrial humanoid robots. Founded in Paris in 2012 by engineers - some with personal ties to degenerative mobility disease - it created Atalante X, a hands-free clinical exoskeleton now used in more than 100 rehabilitation centers, and Eve, the first self-balancing personal exoskeleton designed for home use without crutches. In 2025 the company extended its gait-control expertise into Calvin, a family of industrial humanoids developed with Renault Group and NVIDIA. Wandercraft's stated aim is to blend frontier AI with high-performance hardware to help people work and walk.
Constant Therapy
Constant Therapy is a Boston-area digital health company that turns speech, language, and cognitive rehabilitation into an AI-personalized app. Spun out of Boston University's Aphasia Research Laboratory in 2012, its platform delivers more than 100,000 evidence-based exercises across 80-plus task categories to people recovering from stroke, traumatic brain injury, aphasia, dementia, and other neurological conditions - and to the clinicians who treat them. A patented NeuroPerformance Engine adapts each session to the individual, extending therapy beyond the clinic and into daily home practice.