misfolded-proteins
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Russ Lebovitz
Russ Lebovitz is the co-founder and CEO of Amprion, a precision brain diagnostics company that built the first commercial seed amplification assay for detecting misfolded alpha-synuclein - the protein at the root of Parkinson's disease and other synucleinopathies. An MD/PhD trained at Washington University in St. Louis and a former research physician at Baylor and Fox Chase Cancer Center, Lebovitz spent years chasing prions after the mad cow scare, then pivoted the same detection science toward common neurodegenerative diseases. His SYNTap test won an FDA Breakthrough Device Designation and is now used in clinical trials and patient care to spot brain disease years before symptoms appear.
Amprion
Amprion is a precision-diagnostics company using Seed Amplification Assay (SAA) technology to detect misfolded proteins - alpha-synuclein, amyloid-beta and tau - in cerebrospinal fluid, giving physicians and drug developers a biological readout of neurodegenerative disease years before symptoms fully emerge. Its flagship SAAmplify-aSYN test (formerly SYNTap) is the first commercially available validated alpha-synuclein SAA, carries an FDA Breakthrough Device Designation, and aims to replace symptom-based guesswork for Parkinson's, Lewy body dementia, Alzheimer's and multiple system atrophy with autopsy-grade certainty.