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biotech1 immunology1 inflammation1 atopic-dermatitis1 antibody-engineering1 kallikrein1 precision-medicine1 genetics-informed1 monoclonal-antibodies1 bispecific-antibody1 drug-discovery1 clinical-stage1 watertown-ma1 i-and-i-disorders1

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CompanyHealthAi

Triveni Bio is a clinical-stage biotechnology company in Watertown, Massachusetts building first-in-class antibody therapeutics for immunological and inflammatory (I&I) diseases. Born from the 2023 merger of Amagma Therapeutics and Modify Therapeutics, the company pairs a genetics-informed approach with advanced antibody engineering to target root-cause biology rather than just downstream inflammation. Its lead program, TRIV-509, is a half-life-extended monoclonal antibody that inhibits active kallikreins 5 and 7 (KLK5/7) and is in a global Phase 2 proof-of-concept study for moderate-to-severe atopic dermatitis. Backed by roughly $223M across Series A and Series B rounds, Triveni aims to repair the skin barrier and break what it calls efficacy ceilings in dermatology and beyond.

$115,000,000Series B

biotechimmunologyinflammationatopic-dermatitisantibody-engineeringklk5-7