il-2
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Synthekine and the Art of Asking Less of IL-2
The Menlo Park biotech began with a wide library of immune signals. Its sharper wager now is whether a carefully tuned IL-2 can improve lung cancer treatment without stirring the whole immune system.
Aron Knickerbocker Built a Career by Following the Data
The Aulos Bioscience CEO has spent three decades moving closer to the work - from the lab, to the deal table, to the small teams where one clear decision can redirect an entire company.
Aulos Bioscience
Aulos Bioscience is a Larkspur, California, clinical-stage immuno-oncology company using artificial intelligence to design antibody therapeutics that unlock the anti-cancer power of interleukin-2 (IL-2). Its lead candidate, imneskibart (AU-007) - described as the first AI-designed human monoclonal antibody to enter human clinical trials - redirects IL-2 away from immune-suppressing regulatory T cells and toward immune-activating effector T cells and NK cells, aiming to treat solid tumors such as melanoma and non-small cell lung cancer while avoiding the toxicity that has limited earlier IL-2 therapies.