crispr-gene-editing
(2)
Sus Clinicals, Inc.
Sus Clinicals, Inc. is a Cincinnati- and Chicago-based biotechnology company commercializing the Oncopig Cancer Model - a genetically engineered pig that develops human-like tumors on demand. Billed as the only FDA-cleared large animal cancer platform, the Oncopig carries KRAS and TP53 mutations found in more than half of human cancers, giving drug, device, and diagnostic developers a predictive testing ground that sits between the mouse and the human clinical trial. Alongside live animal supply, the company runs histology services and a tumor-tissue biorepository, and partners with CROs across the US and Europe.
Wugen
Wugen is a clinical-stage biotechnology company in St. Louis engineering off-the-shelf, allogeneic cell therapies for cancer. Spun out of Washington University in St. Louis in 2018, it builds CRISPR-edited CAR-T cells and cytokine-induced memory NK cells designed to be manufactured once from healthy donors and delivered to many patients. Its lead program, WU-CART-007 (soficabtagene geleucel), is a CD7-targeted allogeneic CAR-T in a pivotal trial for relapsed/refractory T-cell leukemia and lymphoma, carrying FDA Breakthrough Therapy, RMAT, Fast Track, Orphan Drug and Rare Pediatric Disease designations.