computational-biophysics
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Lucas Nivon Is Building the Bridge Between Protein Code and the Wet Lab
He started with a stubborn software problem: brilliant protein-design tools were too hard to use. A decade later, Lucas Nivon is still widening the doorway - now between algorithms, experiments, and open scientific infrastructure.
Nested Therapeutics
Nested Therapeutics is a Cambridge, Massachusetts clinical-stage biotech building small-molecule precision oncology drugs that go after cancer driver mutations long written off as undruggable. Founded in 2021 and launched publicly in 2022 with $125M, the company pairs structural biology, computational biophysics and chemistry to find hidden, druggable pockets in cancer's most stubborn targets. Its lead program, NST-628, is a brain-penetrant pan-RAF/MEK molecular glue for RAS/MAPK-driven solid tumors, now in Phase 1 with early clinical activity reported at AACR 2026.