cleveland-clinic
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Enspire DBS Therapy, Inc.
Enspire DBS Therapy is a Cleveland-based, clinical-stage medical device company commercializing deep brain stimulation (DBS) paired with physical rehabilitation to restore arm and hand function in people living with chronic impairment after a stroke. Spun out of Cleveland Clinic in 2010, the company builds on more than a decade of research targeting the brain's dentate nucleus to re-establish neurological input during rehab. Its DBS-plus-rehab approach showed encouraging results in the first-in-human EDEN trial published in Nature Medicine, and Enspire is now running RESTORE, a multicenter pivotal study aimed at FDA marketing authorization.
Luminai
Luminai is an AI-native workflow automation platform built for the back office of American healthcare. It turns messy, unstructured inputs - faxes, chart notes, insurance forms - into structured data and then runs full administrative workflows like referral intake, patient registration, and denial appeals end to end, with a human in the loop and HIPAA/SOC 2 controls baked in. Founded in 2019 by Kesava Kirupa Dinakaran and Dmitry Dolgopolov, the company started life as customer-support RPA tool DigitalBrain, pivoted entirely into healthcare, and raised a $38M Series B in April 2026 led by Peak XV Partners, with Cleveland Clinic as a flagship partner.
XII Medical
XII Medical is a Union City, California medical device company building a minimally invasive neuromodulation therapy for obstructive sleep apnea (OSA). Founded in 2017 and led by CEO Garrett Schwab, the company is developing an implantable platform designed to be smaller, more flexible and easier to implant than existing nerve-stimulation systems - an alternative for the estimated 425 million people worldwide with moderate-to-severe OSA who struggle with CPAP masks. Backed by Cleveland Clinic, Ajax Health, Omega Funds and Intuitive Ventures, XII Medical closed a $45M Series B in August 2024 to fund product and clinical development.
MediView XR, Inc.
MediView XR is a Cleveland, Ohio med-tech company building augmented-reality 'X-ray vision' for surgeons. Founded in 2017 on Cleveland Clinic intellectual property, MediView's FDA-cleared XR90 platform and OmnifyXR Interventional Suite let clinicians see a patient's 3D anatomy - bone, tissue, organs, and vasculature - holographically projected through the skin during minimally invasive, ultrasound-guided procedures. Backed by GE HealthCare, Mayo Clinic, and Cleveland Clinic, the company raised a $24M Series A in October 2025.