checkpoint-inhibitor
(6)
Pheast Therapeutics
Pheast Therapeutics is a clinical-stage biotech engineering the innate immune system to attack cancer. Its lead drug, PHST001, is an anti-CD24 macrophage checkpoint inhibitor designed to flip the 'don't eat me' signal that solid tumors use to hide from the body's first-line defenders.
HanchorBio Inc. 漢康生技股份有限公司
HanchorBio is a clinical-stage biotechnology company building next-generation cancer and autoimmune therapies on its proprietary Fc-Based Designer Biologics (FBDB) platform. Founded in 2020 by Henlius co-founder Scott Liu, the company engineers multi-target Fc fusion proteins designed to reach tumors that resist conventional PD-1/PD-L1 checkpoint drugs. Its lead candidate, HCB101, is an affinity-optimized SIRPalpha-Fc fusion protein targeting the CD47-SIRPalpha 'don't eat me' pathway, engineered to spare red blood cells and avoid the anemia that sank earlier anti-CD47 programs. With operations spanning Taipei, Shanghai, and the San Francisco Bay Area, HanchorBio is advancing a pipeline across solid and hematologic cancers and autoimmune disease.
OncoC4, Inc.
OncoC4, Inc. is a Rockville, Maryland clinical-stage biopharmaceutical company building first-in-class and best-in-class antibody therapies for hard-to-treat cancers and Alzheimer's disease. Founded by immunologists Yang Liu and Pan Zheng, the company discovered the innate immune checkpoint CD24-Siglec-10 and is advancing a pipeline led by gotistobart (ONC-392), a next-generation anti-CTLA-4 antibody partnered with BioNTech, alongside SIGLEC10, PD-1/VEGF, and CD24-targeting programs.
Tom Smart
Tom Smart is a biotech executive with a 25-year run of taking cancer companies from the lab bench to Wall Street and back again. He currently leads Actym Therapeutics, a cancer-immunotherapy company building bacteria-delivered gene therapies, after a career that ran through AnaptysBio, XOMA, Cell Genesys and Genetics Institute. He helped shepherd the PD-1 checkpoint inhibitor that became GSK's Jemperli, founded and sold an antifungal company, and is named in industry records as a CEO and board member at oncolytic-virus company Seneca Therapeutics. His specialty is the unglamorous middle: financings, partnerships, IPOs and acquisitions that decide whether a promising molecule ever reaches a patient.
Yang Liu
Yang Liu is a cancer immunologist turned serial biotech founder who chairs and runs OncoC4, the Rockville, Maryland company developing next-generation immune checkpoint antibodies. After decades as an endowed professor at NYU, Ohio State, Michigan, and beyond, he co-founded OncoImmune (acquired by Merck for $425M) and then OncoC4, whose lead anti-CTLA-4 antibody gotistobart is in late-stage development with BioNTech. He left full-time academia to take his own discoveries from the bench into patients.
Roy Maute
Roy Maute is co-founder and CEO of Pheast Therapeutics, a clinical-stage biotech in Redwood City, CA, developing macrophage-targeted cancer immunotherapies. Trained at UC Berkeley, Columbia (PhD, Genetics), and Stanford (postdoc under Irving Weissman), Maute has built a career at the intersection of innate immunology and drug development. Before Pheast, he co-founded Ab Initio Biotherapeutics (acquired by Ligand in 2019) and led translational research at Forty Seven Inc. ahead of its $4.9B acquisition by Gilead in 2020. At Pheast, he is advancing PHST001, a novel anti-CD24 antibody that teaches macrophages to eat cancer cells, currently in Phase 1 clinical trials with FDA Fast Track Designation for ovarian cancer.