EBR Systems, Inc.

EBR Systems is a Sunnyvale, California medical device company that developed the WiSE System, the world's first and only leadless left ventricular endocardial pacing device for cardiac resynchronization therapy. About the size of a grain of rice, the ultrasound-powered electrode paces the inside of the heart's left ventricle without wires, working alongside a patient's existing pacemaker or defibrillator. After its pivotal SOLVE-CRT trial was halted early for success, the WiSE System won U.S. FDA approval in April 2025 and began its commercial launch for heart failure patients who have run out of conventional options.