Tagged: bionav
2 results
Unravel Biosciences
Unravel Biosciences is a clinical-stage therapeutics company spun out of Harvard's Wyss Institute that starts with a patient's RNA rather than a drug target. Its BioNAV probabilistic network model of human health screens 40,000-plus compounds in silico - reporting roughly 200x the hit rate of conventional screens - to find existing molecules that can push a disease back toward health. The company validates predictions in engineered whole-organism models (including CRISPR-edited tadpoles) and then in patients, aiming to bring effective, lower-cost therapies to rare and overlooked diseases. Its lead asset, RVL-001 (a proprietary formulation of vorinostat), holds FDA Orphan Drug Designation for Rett syndrome and has entered clinical studies.
Richard Novak
Richard Novak is a bioengineer and entrepreneur who co-founded and leads Unravel Biosciences, a rare disease therapeutics company built on its BioNAV platform that uses RNA network analysis to ask whether a drug will help real patients before working backward to find its target. A former lead engineer at Harvard's Wyss Institute with 15+ years in drug discovery systems, he also founded the swab company Rhinostics during the COVID-19 pandemic and the science-education nonprofit Future Scientist. Novak holds a PhD in Bioengineering from UC Berkeley and a BS in Biology from Emory, and is a 2024 Termeer Fellow.