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targeted protein degradation1 biotech1 biopharmaceutical1 oncology1 autoimmune disease1 e3 ligase1 ubiquitin-proteasome system1 btk degrader1 drug discovery1 clinical-stage1 nasdaq nrix1 del-ai1 degrader antibody conjugates1 cbl-b inhibitor1

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Nurix Therapeutics

Nurix Therapeutics is a clinical-stage biopharmaceutical company in San Francisco pioneering targeted protein degradation - medicines that destroy disease-causing proteins rather than merely blocking them. Built on its DELigase discovery engine that harnesses the cell's ubiquitin-proteasome system and DNA-encoded library screening, Nurix is advancing a pipeline of degraders and degrader antibody conjugates for cancer and autoimmune disease, led by the BTK degrader bexobrutideg (NX-5948). The company is partnered with Roche, Sanofi, Gilead, and Pfizer (via Seagen) and trades on Nasdaq under NRIX.

San FranciscoHQ

$209 million (gross; ~$238.5M with overallotment)IPO (Nasdaq: NRIX)

targeted protein degradationbiotechbiopharmaceuticaloncologyautoimmune diseasee3 ligase