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biotechnology1 metabolic disease1 obesity1 clinical-stage1 biopharmaceutical1 mitochondrial protonophore1 MASH1 type 2 diabetes1 energy homeostasis1 palo alto1 drug development1 TLC-67401 life sciences1

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OrsoBio

OrsoBio is a Palo Alto clinical-stage biopharmaceutical company developing first-in-class small-molecule therapies for severe metabolic disorders including obesity, type 2 diabetes, and MASH. Its lead approach uses liver-targeted mitochondrial protonophores that restore cellular energy homeostasis - biology inspired partly by how hibernating bears manage their metabolism ("orso" is Italian for bear). Incubated by Samsara BioCapital and led by former Gilead liver-disease leaders, the company has raised roughly $256M across four rounds and reported Phase 1b/2a data showing its lead candidate TLC-6740 added meaningful weight loss on top of the incretin drug tirzepatide.

biotechnology · metabolic diseaseRead →