Former Silicon Valley founder. AI super angel. The first person Fuel VC sent to Silicon Valley to run the room.
Profile
By the time Fuel Venture Capital announced Selene Casabal as its Managing General Partner and Chief Venture Officer in October 2025, her track record had already done most of the talking. She had founded a retail tech company, sold it to b8ta - the largest physical retail technology operator in the US, Dubai, and Japan - served as a Sequoia Capital Scout, planted herself at South Park Commons while early Anthropic and Cognition AI teams were still sketching out their ideas, and quietly angel-invested in Perplexity, Replit, Impulse Space, and Serve Robotics. Thirty-plus bets in frontier technology. Two exits. And a front-row seat to the AI wave before most of the industry realized a wave was coming.
Now she runs the room. As Fuel VC's first-ever Silicon Valley director, Casabal is responsible for deploying more than $100 million in AI-focused capital on behalf of a Miami-based firm managing approximately $550 million across five funds. The mandate is clear: find the builders at the frontier, back them early, and scale them with operational conviction that only a founder can bring to the table.
"If women aren't part of that process, we're missing half the intelligence the world has to offer."- Selene Casabal, on AI's gender gap
Casabal grew up in Miami. She went to Penn, where she stumbled into entrepreneurship the way most great founders do - sideways, by accident, with classmates. In her senior year, she launched an early Amazon third-party seller business. It generated unexpected revenue. Not a unicorn, but a proof of concept: markets reward people who move before the crowd notices. That lesson stuck.
She also won the Penn in Washington scholarship, working in Senator Bob Casey's judiciary office on immigration, healthcare, and civil rights policy. The combination of startup instincts and policy fluency would prove useful later - when the technologies she was backing started touching regulated industries, public infrastructure, and the governance of AI itself.
Her flagship company, Re:store, was the kind of venture that sounds obvious in retrospect. Physical retail was not dead - it was misfiring. Casabal built a company around making retail spaces work for technology brands that didn't fit the traditional shelf model. b8ta acquired it. The acquisition made her an operator inside the largest physical tech retail network in the world, and it made her an unusually credible voice on the intersection of physical and digital commerce.
"AI doesn't care what you look like or where you went to school. It's democratizing in a way that few technologies ever have been."- Selene Casabal
After b8ta, she moved into advising - Popshop Live, then Chanel's Global Open Innovation team, where she was handpicked to advise C-suite executives on product strategy and emerging technology. The Chanel relationship is worth noting. It is unusual. Most frontier tech investors do not have longstanding advisory relationships with French luxury fashion houses. Casabal does, because she can translate the language of frontier technology into the language of brand strategy without losing something in the translation.
Intel came next. As executive advisor to Intel Ignite, the chip giant's deep tech acceleration program, she worked directly with founders building in cybersecurity, AI, and robotics. She was not a bystander. She was evaluating companies, mentoring teams, and getting a detailed view of where the hard problems in AI infrastructure actually lived.
The Sequoia Scout partnership changed everything. It gave her a formal vehicle for the angel investing she had been doing informally and gave her access to deal flow and due diligence infrastructure at the level of one of Silicon Valley's most respected institutions. Her portfolio from that period - Perplexity, Replit, Impulse Space, Serve Robotics - reflects genuine conviction, not trend-chasing. Perplexity was not a consensus bet when she made it. Neither was Impulse Space, which is building in commercial space propulsion. These are founder-first bets, made early, held with conviction.
South Park Commons is where she spent the years between her Scout partnership and Fuel VC. The San Francisco-based community of technologists is known for incubating ideas before they become companies. The people who would go on to found Anthropic and Cognition AI were working through their ideas in that same physical and intellectual community while Casabal was there. Whether or not she invested directly in those companies, the proximity shaped her understanding of what frontier AI actually looks like before it has a pitch deck.
At Fuel VC, she is combining all of it. The operational credibility of a founder with two exits. The pattern recognition of a Sequoia Scout. The deep tech fluency of an Intel advisor. The AI thesis of someone who was in the room when the current wave was forming. Her mandate is not just to deploy capital but to reshape Fuel VC's identity as a player in the AI ecosystem, and to do it from both coasts - the firm's Miami roots and her Silicon Valley presence functioning as complementary advantages rather than competing priorities.
"Empowering women in tech isn't just equity - it's smart business."- Selene Casabal
The gender thesis runs through everything. Only about 2% of venture capital dollars flow to women-led startups. Casabal has said plainly that she sees this as a market inefficiency, not just a moral failure. Her specific interest in women-led AI startups is grounded in a pragmatic argument: if the technology reshaping every industry is being built almost entirely by one demographic, the resulting tools will reflect those gaps. She is not the first person to make this argument, but she is making it from the position of someone who has now backed companies backed by Sequoia, Benchmark, and Khosla - which is a different conversation than the one most equity advocates are having.
In early 2026, she appeared in Refresh Miami's annual roundup of the VCs writing the checks - a fitting entry point for a year in which Fuel VC is expected to close a significant new round of AI-focused deals. The firm already has two unicorns in its portfolio across five funds. Casabal's job is to find the next ones before the price reflects the consensus.
Career Arc
Her years at South Park Commons - seated alongside the people who would go on to found Anthropic and Cognition AI - gave her pattern recognition that no amount of deal flow analysis could replicate.
Casabal frames this not as a moral argument but as a market inefficiency - the kind that generates outsized returns for investors willing to look where others aren't.
Portfolio
Casabal's angel portfolio spans AI search, developer tools, commercial space, and autonomous robotics. Portfolio companies have raised hundreds of millions from Sequoia, Benchmark, and Khosla Ventures.
In Her Own Words
"If women aren't part of that process, we're missing half the intelligence the world has to offer."
"AI doesn't care what you look like or where you went to school. It's democratizing in a way that few technologies ever have been."
"It's about giving people confidence. Whether it's writing an email, launching a business, or designing a product, AI is letting more people express themselves and contribute."
"Empowering women in tech isn't just equity - it's smart business."
Achievements
Built and sold a retail technology company to b8ta, which at the time operated physical tech retail across the United States, Dubai, and Japan.
One of a small number of investors selected to source and make investments through Sequoia's Scout program, giving her formal institutional backing for her angel thesis.
Member of the San Francisco-based community that incubated founding teams including early contributors to Anthropic and Cognition AI.
Handpicked by Chanel's Global Open Innovation Officer to advise C-suite leadership on product strategy and emerging technology - an unusual pairing that reflects her cross-sector fluency.
Supported founders building in cybersecurity, AI, and robotics through Intel's flagship acceleration program for deep tech startups.
Named Managing GP and CVO, becoming the firm's first-ever Silicon Valley hire, tasked with deploying $100M+ in AI-focused capital from a fund managing $550M across five vehicles.
Details Worth Knowing