MOMA Therapeutics is a Cambridge, Massachusetts biotech building precision small-molecule medicines against 'molecular machines' - the highly dynamic, shape-shifting enzymes (ATPases, GTPases and related proteins) that power cellular processes and underlie cancer and other diseases. Spun out of Third Rock Ventures in 2020 by four academic leaders in protein biophysics and structural biology, MOMA's proprietary KNOMATIC platform fuses deep structural insight, advanced hit-finding (fragment and DNA-encoded library screening) and machine-learning-driven lead optimization to drug targets long considered intractable. The company has raised about $236M, advanced its first oncology program into the clinic, and partnered with Roche and Bayer.
Neomorph is a San Diego clinical-stage biotech building molecular glue degraders - small molecules that recruit the cell's own disposal machinery to destroy disease-driving proteins long written off as 'undruggable.' Founded in 2020 out of Deerfield Management with scientific founders who decoded how thalidomide-class drugs work, the company has assembled what it calls the world's largest proprietary molecular glue target space across a broad portfolio of E3 ubiquitin ligases. It has signed multibillion-dollar discovery pacts with AbbVie, Novo Nordisk, and Biogen, dosed its first patient with lead candidate NEO-811 in kidney cancer, and raised roughly $209M across Series A and B.
Bryan Faust, PhD is an Investment Partner on the Bio + Health team at Andreessen Horowitz (a16z), where he backs seed and Series A companies at the intersection of biology and technology. A trained biophysicist with a PhD from UCSF, he published research in Nature, Science, and Cell before pivoting to venture—studying antibody-protein interactions, GPCR signaling, and COVID-19 nanobodies along the way. At a16z he has co-led investments in Stipple Bio, Tessera Labs, Gate Bioscience, and Formation Bio, and writes widely on AI in life sciences, biotech financing, and the coming era of programmable medicine. When he's not reading pitch decks, he's surfing, roasting coffee, or hunting down the perfect tacos al pastor.