Breaking
FOUNDED 2016 — Cure Genetics, Suzhou SERIES B — $60M raised, December 2021 PLATFORMS — AIMS CAR-NKT + VELP AAV PEDIGREE — Tsinghua Ph.D., Yale postdoc PUBLISHED — 13 papers, Nature & Molecular Cell PARTNERS — Boehringer Ingelheim, Qiming, Advantech
Yuanyuan Xu, founder and CEO of Cure Genetics
Founder · Scientist · CEO

Yuanyuan Xu

She spent years figuring out how cells repair broken DNA. Then she started a company to act on that biology, and named it after the thing it has not done yet: Cure Genetics.

Gene Therapy Cell Therapy Structural Biology Suzhou, China
The Story

A crystallographer who refused to stay at the bench

Today Yuanyuan Xu runs a clinical-stage biotech from Suzhou Industrial Park, a place engineered specifically to turn scientists into companies. Cure Genetics, the firm she founded in July 2016, is small on paper - roughly a dozen people - and outsized in ambition: first-in-class cell and gene therapies for solid tumors and inherited disease, the two corners of medicine where the failure rate is highest and the patients have run out of other doors to knock on.

The work splits into two bets. One is a cell therapy platform called AIMS CAR-NKT, built on invariant natural killer T cells - a rarer, stranger cousin of the T cells that power conventional CAR-T. The other is VELP, a directed-evolution engine for designing new AAV capsids, the protein shells that ferry genetic payloads into the body. One platform attacks tumors. The other rebuilds the delivery truck. Xu wants both, which tells you something about how she thinks: not in products, in platforms.

That instinct comes from where she started. Xu earned her Ph.D. in the Department of Biology at Tsinghua University, under the academician Rao Zihe, one of China's most decorated structural biologists. Then she crossed the Pacific for a postdoc at Yale, studying the proteins that govern DNA damage, repair, and the slow slide toward cancer. Her name sits on 13 papers in the journals that scientists frame and hang on the wall - Nature, Nature Structural & Molecular Biology, Molecular Cell.

It would have been a perfectly respectable life. Solve a structure, publish it, solve the next one. Instead, in 2016, she walked away from the comfort of the academic ladder to do the much harder thing: convince investors, hire scientists better than her in their narrow lanes, and try to push a molecule all the way through a clinical trial. The biology she had studied from the outside - how DNA breaks, how it gets stitched back together - became the raw material she now wanted to engineer.

She did not do it alone. Cure Genetics was co-founded with Yanni Lin, the company's chief scientist, who holds a joint Ph.D. from Georgia Tech and Emory and a decade in gene editing. Around them Xu assembled the kind of bench that signals seriousness to anyone reading a pitch deck: a chief scientific officer with twenty-plus years and a stint as an executive vice president at Celularity, a clinical lead who has shepherded close to ten IND submissions through major pharma, a protein engineer who built the VELP platform from scratch.

The money followed the people. In August 2018, Cure Genetics closed a $17 million Series A led by Qiming Venture Partners - whose Nisa Leung pointed to the company's "outstanding technology platform and the top-class talents" as the reason for her confidence. CTS Capital and Ascendin Investment joined. Three years later, in December 2021, the company raised a $60 million Series B to push its cell therapy candidates for blood and solid tumors toward and through the clinic. Total funding now sits near $88.9 million, with Advantech Capital added to the cap table.

"Being a unique player of this field, we have recruited top-tier scientists and business partners to develop and promote our proprietary technology platform." — Yuanyuan Xu, on the Series A

Read that quote twice and you notice what is missing. No moonshot rhetoric, no promise to cure cancer by a particular Tuesday. Just an inventory of the two things she believes actually decide outcomes in biotech: the platform and the people you point at it. It is the sentence of someone who has watched enough science fail to know that the idea is the cheap part.

The partnerships tell the same story. In January 2021, Cure Genetics signed a deal with Boehringer Ingelheim, the kind of name that does not put its logo next to a startup's without sending its own scientists to kick the tires first. In September 2023 came a collaboration with Frametact Limited. For a company of thirteen people headquartered far from Boston or the Bay, that is a lot of validation arriving from a lot of directions.

Xu has not fully left academia behind, either. She holds a professorship at Suzhou University, and the Chinese government has stamped her with a small stack of talent honors - Jiangsu Province Innovation and Entrepreneurship Talent, Gusu Innovation and Entrepreneurship Leading Talent, Suzhou Industrial Park Science and Technology Leading Talent. The titles are bureaucratic. What they signal is not: in China's biotech buildout, she is one of the people the system is betting on.

The honest assessment is that the verdict is not in. Cure Genetics is clinical-stage, which is industry shorthand for "the science is real and the hard part is still ahead." CAR-NKT cells and engineered AAV capsids are frontier ideas, and the frontier is where most companies die. But the shape of the bet is unusually coherent. A founder who studied the molecular machinery of disease, building tools to rewrite it, surrounded by specialists she recruited precisely because they know more than she does about their corner of the problem.

The name she chose still reads like a dare. Cure Genetics. She is working on it.

By the Numbers

The ledger so far

2016
Company founded
$88.9M
Total funding raised
13
Papers published
2
Proprietary platforms
The Science

Two platforms, one logic

Cell Therapy

AIMS CAR-NKT

A cell therapy platform built on invariant natural killer T cells - a rarer relative of the T cells behind conventional CAR-T. The aim: send a smarter scout into the hostile terrain of solid tumors, where ordinary engineered cells tend to get lost.

Gene Delivery

VELP™ AAV

A directed-evolution engine for discovering new AAV serotypes - the viral shells that carry gene therapy payloads. If the cell therapy is the cargo, VELP is an attempt to design a better delivery truck for the brain, the heart, and beyond.

The Arc

From the bench to the boardroom

Before 2016
Ph.D. at Tsinghua University under academician Rao Zihe, then a Yale postdoc studying the proteins of DNA damage, repair, and tumorigenesis. Thirteen papers in Nature-tier journals.
July 2016
Founds Cure Genetics in Suzhou with co-founder and chief scientist Yanni Lin.
August 2018
Closes a $17M Series A led by Qiming Venture Partners, with CTS Capital and Ascendin Investment.
January 2021
Strikes a partnership with Boehringer Ingelheim.
December 2021
Raises a $60M Series B to advance cell therapy candidates for hematological and solid tumors.
September 2023
Enters a collaboration with Frametact Limited.
Credentials
Tsinghua UniversityPh.D., Department of Biology — advised by Academician Rao Zihe
Yale UniversityPostdoctoral fellow — protein structure, DNA damage & repair
Suzhou UniversityProfessorship
Curiosities

Things worth knowing

01

Her two platforms have names that sound like rival arcade games: AIMS CAR-NKT and VELP. Both are dead serious science.

02

She studied how DNA gets repaired - then built a company partly around editing it. The biology she observed became the biology she engineers.

03

Cure Genetics runs lean, around 13 people, while taking on some of the hardest targets in oncology.

04

Co-founder Yanni Lin holds a joint Ph.D. from Georgia Tech and Emory and a decade in gene editing.

05

Boehringer Ingelheim partnered with the company in 2021 - rare validation for a thirteen-person firm far from the usual biotech hubs.

06

The government calls her a "leading talent" three times over. The titles are bureaucratic; the bet behind them is not.

Spread It

Share this profile