# Shawn Manchester

> Shawn Manchester is the CEO of Triplebar, an Emeryville-and-Oakland based biotech building generative AI 'genome language models' paired with ultra-high-throughput phenotypic screening to slash the cost of biologic therapeutics and food proteins. A chemical engineer by training (BS Brown, PhD MIT), he was the lead scientist in the first AI-versus-human strain engineering contest at Zymergen before joining Triplebar in 2021, where he rose from VP of Product to COO to CEO in March 2025.

- **Role:** Chief Executive Officer at Triplebar
- **Organizations:** Triplebar, Zymergen, The Production Board, MIT, Brown University
- **Nationality:** American
- **Education:** BS, Chemical Engineering, Brown University, PhD, Chemical Engineering, Massachusetts Institute of Technology (MIT)
- **Known for:** Promoted to CEO of Triplebar in March 2025 after rising through VP of Product and COO roles, Lead scientist in the first AI-versus-human strain engineering test at Zymergen, Closed partner relationships at Zymergen translating to more than $10M in revenue

## Career timeline

- **MIT** — PhD candidate and postdoctoral associate researching chemical engineering and synthetic biology
- **~2014-2021** — Seven years in technical and strategic product roles at Zymergen, Inc.; lead scientist in the first AI-versus-human strain engineering test; BD lead on partnerships generating over $10M in revenue
- **pre-2021** — Entrepreneur in Residence (EIR) at The Production Board
- **2021** — Joined Triplebar as VP of Product
- **2021-2025** — Served as VP of Product, then Chief Operating Officer at Triplebar
- **2025-03** — Appointed Chief Executive Officer of Triplebar

## Achievements

- Promoted to CEO of Triplebar in March 2025 after rising through VP of Product and COO roles
- Lead scientist in the first AI-versus-human strain engineering test at Zymergen
- Closed partner relationships at Zymergen translating to more than $10M in revenue
- Early pioneer in applying high-throughput screening and machine learning to strain and cell line development
- PhD in Chemical Engineering from MIT

## Latest updates

- **2025-03** — Appointed Chief Executive Officer of Triplebar, succeeding to the role from Chief Operating Officer.

## Links

- Website: https://triplebar.com
- LinkedIn: http://www.linkedin.com/in/shawn-manchester-04931289

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Profile page: https://yespress.io/shawn-manchester
Published by YesPress — https://yespress.io
Last updated: 2026-06-05