# Pyxis Partners

> Pyxis Partners is a Washington, D.C. public affairs and engagement firm that helps health organizations move between federal policy, biomedical research and communities historically left out of both. Founded in 2020 by longtime patient advocate Michael Manganiello, the firm sells government relations, policy analysis, communications and community-engagement work to public agencies, researchers, health plans, pharmaceutical companies and advocacy groups.

- **Founded:** 2020
- **Headquarters:** Washington, United States
- **Founders:** Michael Manganiello (Founder and CEO)
- **Products:** Community engagement, Government relations, Policy and advocacy, Strategic communications, Clinical Trial Diversity Action Plan support
- **Notable:** Built the Community and Provider Gateway Initiative into a national network of more than 100 community-based organizations., Supported The Kennedy Forum's first-of-its-kind guide containing more than 200 federal mental-health and substance-use policy recommendations., Helped the American Liver Foundation secure authorization for a nationwide federal study of MASLD prevalence in the FY2024 Labor-HHS appropriations measure.

## Products & services

- **Community engagement** — Designs national and local engagement strategies, builds networks of trusted organizations, facilitates community conversations and connects historically underrepresented groups with research and policy programs.
- **Government relations** — Provides federal policy monitoring, congressional and agency engagement, impact analysis, decision-maker mapping, meeting preparation, coalition coordination and public-comment development.
- **Policy and advocacy** — Researches policy, develops recommendations, builds coalitions and combines evidence with patient and community stories to move legislative and regulatory priorities.
- **Strategic communications** — Develops messaging, campaigns and messenger strategies for health organizations navigating public policy and community trust.
- **Clinical Trial Diversity Action Plan support** — With Rx4good, helps biopharmaceutical sponsors listen to representative communities, co-design engagement and communications, and prepare for FDA diversity-action-plan requirements.

## Achievements

- Built the Community and Provider Gateway Initiative into a national network of more than 100 community-based organizations.
- Supported The Kennedy Forum's first-of-its-kind guide containing more than 200 federal mental-health and substance-use policy recommendations.
- Helped the American Liver Foundation secure authorization for a nationwide federal study of MASLD prevalence in the FY2024 Labor-HHS appropriations measure.
- Supported advocacy for mandatory 12-month continuous Medicaid and CHIP eligibility for children enacted by Congress at the end of 2022.
- Developed an All of Us Research Scholar Program model supporting 50 scholars and 25 mentors.
- Facilitated NIH community conversations on emerging technology and personal health data in six cities plus virtual sessions for additional populations.
- Received $2.05 million in NIH funding in FY2024; NIH records list $3.20 million across two Pyxis awards in FY2025.
- Certified as an LGBT Business Enterprise by NGLCC and as a District of Columbia Certified Business Enterprise.

## Latest updates

- **2026-06** — Pyxis highlighted continued All of Us work, including community and researcher engagement around a participant community the company said had grown beyond 828,000.
- **2026-05** — CEO Michael Manganiello joined UCB's External Sustainability Advisory Board.
- **2025-08** — HHS records show Pyxis received FY2025 NIH award actions bringing listed funding across two awards to approximately $3.20 million.
- **2024-09** — Manganiello appeared in the documentary Super/Man: The Christopher Reeve Story, reflecting his earlier advocacy work with the Reeve Foundation.
- **2024-03** — Pyxis and Rx4good announced a joint service for biopharmaceutical companies preparing community-informed clinical-trial diversity action plans.

## Links

- Website: https://www.pyxispartners.co
- LinkedIn: https://www.linkedin.com/company/pyxispartners
- Twitter/X: https://twitter.com/pyxistweets

---

Profile page: https://yespress.io/pyxis-partners
Published by YesPress — https://yespress.io
Last updated: 2026-09-21