# Pheast Therapeutics

> Pheast Therapeutics is a clinical-stage biotech engineering the innate immune system to attack cancer. Its lead drug, PHST001, is an anti-CD24 macrophage checkpoint inhibitor designed to flip the 'don't eat me' signal that solid tumors use to hide from the body's first-line defenders.

- **Founded:** 2020
- **Headquarters:** Redwood City, California, United States
- **Founders:** Irving Weissman (Co-founder, Scientific Advisor), Ravi Majeti (Co-founder), Amira Barkal (Co-founder, former interim CEO), Roy Maute (Co-founder, Chief Scientific Officer)
- **Team size:** ~40 employees
- **Products:** PHST001, PHST677
- **Notable:** $76M Series A raised in 2022, FDA Fast Track Designation for PHST001 in ovarian cancer (June 2025), First patient dosed in Phase 1b combination cohorts (March 2026)

## Products & services

- **PHST001** — An IgG4 anti-CD24 monoclonal antibody and macrophage checkpoint inhibitor in Phase 1 trials for ovarian, endometrial, and cholangiocarcinoma cancers.
- **PHST677** — A preclinical bispecific antibody-drug conjugate targeting CDH1 and Nectin-4.

## Achievements

- $76M Series A raised in 2022
- FDA Fast Track Designation for PHST001 in ovarian cancer (June 2025)
- First patient dosed in Phase 1b combination cohorts (March 2026)
- Initial Phase 1a data presented at AACR 2026 showing target engagement
- Lineage from Forty Seven (acquired by Gilead in 2020 for ~$4.9B)

## Latest updates

- **2026-04** — Reported initial Phase 1a data for PHST001 at AACR 2026 - well-tolerated, linear PK, increasing CD24 receptor occupancy.
- **2026-03** — First patient dosed in Phase 1b combination cohorts.
- **2025-11** — Latest venture funding milestone.
- **2025-06** — FDA Fast Track Designation granted for PHST001 in ovarian cancer.
- **2024-11** — Presented new preclinical PHST001 data at SITC 2024.
- **2022-04** — Emerged from stealth with $76M Series A.

## Links

- Website: https://pheast.com
- LinkedIn: https://www.linkedin.com/company/pheast-therapeutics
- Twitter/X: https://twitter.com/pheast_inc

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Profile page: https://yespress.io/pheast-therapeutics
Published by YesPress — https://yespress.io
Last updated: 2026-06-28