# Paul Scagnetti

> Paul Scagnetti is the CEO of ONI (Oxford Nanoimaging), the Oxford spin-out behind the Nanoimager, the first desktop super-resolution microscope to see single molecules at 20 nanometer resolution. A mechanical engineer with a PhD from MIT and 25+ years in life sciences and instruments, he left a job he loved at Illumina in February 2023 to bet that making Nobel-grade imaging simple enough for any lab would change drug discovery. In January 2025 he shipped the Aplo Scope, which he calls the biggest launch in ONI's history.

- **Role:** Chief Executive Officer at ONI (Oxford Nanoimaging)
- **Organizations:** ONI (Oxford Nanoimaging), Illumina, FEI Company, Intel
- **Nationality:** American
- **Education:** Ph.D. in Mechanical Engineering, Massachusetts Institute of Technology (MIT), MBA, University of Oregon, Master's in Mechanical Engineering, Boston University
- **Known for:** Appointed CEO of ONI in February 2023 to lead its next chapter of commercial growth, Led the January 2025 launch of the Aplo Scope, a compact super-resolution microscope reaching 20 nm resolution, Previously led M&A, partnerships and licensing as VP of Corporate and Business Development at Illumina

## Career timeline

- **2001** — Senior Manager of Strategic Planning and Corporate Development at FEI Company
- **2003** — Director of Strategic Planning and Corporate Development at FEI Company
- **2007** — VP and General Manager, Natural Resources Business Unit, FEI Company
- **2012** — VP and General Manager, Science Business Group, FEI Company
- **2015** — Senior Director of Corporate & Venture Development at Illumina
- **2020** — VP of Corporate and Business Development at Illumina, leading M&A, partnerships, and licensing
- **2023** — Appointed CEO of ONI (Oxford Nanoimaging), effective February 27
- **2025** — Launched the Aplo Scope, ONI's biggest product launch, achieving 20 nm resolution

## Achievements

- Appointed CEO of ONI in February 2023 to lead its next chapter of commercial growth
- Led the January 2025 launch of the Aplo Scope, a compact super-resolution microscope reaching 20 nm resolution
- Previously led M&A, partnerships and licensing as VP of Corporate and Business Development at Illumina
- Held international general management and business development roles at FEI Company and Intel
- Brings 25+ years of experience across life sciences and technology instruments

## Latest updates

- **2025-01** — Led ONI's launch of the Aplo Scope, calling it the biggest launch in the company's history; the instrument reaches 20 nm resolution and aims to cut drug target validation time.
- **2023-08** — Marked his first 180 days as CEO with a public reflection on ONI's mission and the future of super-resolution microscopy.

## Links

- Website: https://oni.bio
- LinkedIn: http://www.linkedin.com/in/paulscagnetti
- Twitter/X: https://twitter.com/oniHQ
- Facebook: https://www.facebook.com/ONIdotBIO/

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Profile page: https://yespress.io/paul-scagnetti
Published by YesPress — https://yespress.io
Last updated: 2026-07-01