# Life Biosciences

> Boston-based Life Biosciences develops experimental medicines intended to restore the function of aged or injured cells. Its lead candidate, ER-100, uses controlled expression of three reprogramming factors and entered a Phase 1 trial in 2026 for open-angle glaucoma and non-arteritic anterior ischemic optic neuropathy. The company has not reported human efficacy results.

- **Founded:** 2017
- **Headquarters:** Boston, United States
- **Founders:** David A. Sinclair (Chairman and co-founder), Tristan Edwards (Co-founder and former CEO)
- **Products:** ER-100, Epigenetic Restoration platform, ER-300
- **Notable:** Reported restoration of visual function in a nonhuman-primate optic-neuropathy model at ARVO 2023., FDA cleared ER-100's investigational new drug application in January 2026., First ER-100 Phase 1 participant dosed in June 2026.

## Products & services

- **ER-100** — Investigational AAV-based epigenetic restoration therapy in Phase 1 testing for open-angle glaucoma and NAION; controlled OCT4, SOX2 and KLF4 expression is intended to restore retinal ganglion-cell function.
- **Epigenetic Restoration platform** — Research platform for partial reprogramming of aged or injured cells using controlled expression of OSK transcription factors.
- **ER-300** — Preclinical liver-disease candidate; company reported biomarker improvements in a mouse model of MASH at ARDD 2025.

## Achievements

- Reported restoration of visual function in a nonhuman-primate optic-neuropathy model at ARVO 2023.
- FDA cleared ER-100's investigational new drug application in January 2026.
- First ER-100 Phase 1 participant dosed in June 2026.
- Great Place To Work certification for 2026-2027.

## Latest updates

- **2026-08** — Appointed former Spark Therapeutics CFO Stephen Webster to its board.
- **2026-06** — Dosed the first participant in ER-100's Phase 1 study.
- **2026-04** — Closed an $80 million Series D financing to support the trial and platform research.
- **2026-01** — Announced FDA IND clearance for ER-100.

## Links

- Website: https://www.lifebiosciences.com/
- LinkedIn: https://www.linkedin.com/company/lifebiosciences
- Twitter/X: https://x.com/lifebiosciences
- Facebook: https://www.facebook.com/lifebiosciences

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Profile page: https://yespress.io/life-biosciences
Published by YesPress — https://yespress.io
Last updated: 2026-09-29