# LASE Innovation Inc.

> LASE Innovation Inc. is a Boston-area techbio company commercializing LP™ Optical Cell Barcoding, a laser-particle technology that tags individual cells with narrowband light signatures tuned across more than 1,000 wavelengths. Spun out of the Wellman Center at Massachusetts General Hospital and MIT, the platform lets researchers run multiple passes of flow cytometry on the same sample, track the same cells over time, and connect single-cell data across flow, imaging and sequencing. The company is turning a long-standing limitation of flow cytometry - that you generally read a cell once and lose it - into a repeatable, trackable measurement.

- **Founded:** 2019
- **Headquarters:** Waltham, Massachusetts, United States
- **Founders:** Sheldon J. J. Kwok (CEO & Co-Founder), Seok-Hyun (Andy) Yun (Co-Founder / Scientific Founder)
- **Team size:** ~10-11 employees
- **Products:** LP™ Optical Cell Barcoding Platform, Multi-pass Flow™ Cytometry, Time-lapse Flow™ Cytometry, Time-lapse™ TITAN Assay Service
- **Notable:** Published 'High-dimensional multi-pass flow cytometry via spectrally encoded cellular barcoding' in Nature Biomedical Engineering (Nov 2023), Peer-reviewed work in Cytometry Part A (2024) on overcoming fixation and permeabilization challenges via optical barcoding and multi-pass acquisition, Developed laser particles with narrowband emission under 0.2nm tunable to 1,000+ wavelengths

## Products & services

- **LP™ Optical Cell Barcoding Platform** — Light-emitting laser particles (nano-to-micron scale) with narrowband emission under 0.2nm, tunable across more than 1,000 wavelengths, attached to cells to give each one a unique, non-destructive optical barcode.
- **Multi-pass Flow™ Cytometry** — Barcoding lets a single sample be run through flow cytometry multiple times, breaking large, hard-to-design antibody panels into smaller, more spectrally separated ones.
- **Time-lapse Flow™ Cytometry** — Tracks the same individual cells across multiple time points, revealing how marker expression changes per cell rather than across populations.
- **Time-lapse™ TITAN Assay Service** — A flow service, launched with Talon Biomarkers, that tracks the same individual T cells before and after activation to reveal activation kinetics at single-cell resolution.

## Achievements

- Published 'High-dimensional multi-pass flow cytometry via spectrally encoded cellular barcoding' in Nature Biomedical Engineering (Nov 2023)
- Peer-reviewed work in Cytometry Part A (2024) on overcoming fixation and permeabilization challenges via optical barcoding and multi-pass acquisition
- Developed laser particles with narrowband emission under 0.2nm tunable to 1,000+ wavelengths
- NCI renewed its SBIR grant as a Direct-to-Phase II award (Oct 2024)
- Stood up a ~6,000 sq ft BSL-2+ facility in Waltham, MA with LASE-enabled cytometers, microscopy and cryogenic storage

## Latest updates

- **2024-10** — NCI renewed LASE's SBIR funding as a Direct-to-Phase II award.
- **2024-07** — Dr. Yulia Shulga appointed Principal Scientist, Biology.
- **2024-01** — Launched the Time-lapse TITAN Assay Service with Talon Biomarkers.
- **2023-12** — Trevor Brown appointed Chief Commercial Officer.
- **2023-11** — Published multi-pass flow cytometry barcoding work in Nature Biomedical Engineering.

## Links

- Website: https://laseinnovation.com
- LinkedIn: https://www.linkedin.com/company/lase-innovation/

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Profile page: https://yespress.io/lase-innovation-inc
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Last updated: 2026-06-14