# Frekil

> Frekil is an AI-powered real-world evidence (RWE) platform for life sciences that turns raw clinical data - EHR, claims, and registries - into regulatory-grade evidence in minutes instead of months. Its agentic pipeline runs the full study lifecycle, from literature review and cohort building through statistical analysis plan generation and final reports, while keeping clinical data isolated from AI models. Founded in 2025 by IIT Bombay alumni Nikhil Tiwari and Shivesh Gupta, Frekil is a Y Combinator (X25/P25) company serving pharma, biotech, CROs, and academic researchers.

- **Founded:** 2025
- **Headquarters:** San Francisco, California, United States
- **Founders:** Nikhil Tiwari (Co-founder & CEO), Shivesh Gupta (Co-founder & CTO)
- **Team size:** 3
- **Products:** Frekil RWE Platform, 8-Stage Agent Pipeline, Data-Isolated Architecture
- **Notable:** Accepted into Y Combinator's X25 (Spring 2025) batch., Built an end-to-end 8-stage agentic RWE pipeline spanning literature review to final report., Designed a data-isolation architecture so clinical data never enters an AI model.

## Products & services

- **Frekil RWE Platform** — An AI-powered platform that connects to EHR, claims, registry, and proprietary datasets and runs the full real-world evidence study lifecycle through conversational, agentic workflows - test hypotheses, build cohorts, and produce publication-ready evidence.
- **8-Stage Agent Pipeline** — An end-to-end sequence of AI agents: Literature Review, Question Clarifier, Cohort Builder, Causal DAG Builder, SAP (Statistical Analysis Plan) Generator, Data Extractor, SAP Executor, and Report Writer - each reviewable and refinable by the user.
- **Data-Isolated Architecture** — A design where no clinical data ever enters an AI model; agents orchestrate analysis while patient-level data stays isolated, and outputs are generated as reproducible R, Python, or SAS code.

## Achievements

- Accepted into Y Combinator's X25 (Spring 2025) batch.
- Built an end-to-end 8-stage agentic RWE pipeline spanning literature review to final report.
- Designed a data-isolation architecture so clinical data never enters an AI model.

## Latest updates

- **2025-04** — Raised a Seed round with participation from Y Combinator and 7BC Venture Capital.
- **2025-06** — Participated in Y Combinator's X25 (Spring 2025) batch.

## Links

- Website: https://frekil.com
- LinkedIn: https://www.linkedin.com/company/frekil
- Twitter/X: https://x.com/frekil_ai

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Profile page: https://yespress.io/frekil-yc-p25
Published by YesPress — https://yespress.io
Last updated: 2026-07-31