# Evercrisp Biosciences

> Evercrisp Biosciences develops computationally designed miniproteins intended to carry oligonucleotides and genome editors into selected tissues. Founded in 2021 by Jennifer Doudna, Tanja Kortemme and Spiros Liras, it remains preclinical. Funding disruption interrupted research in 2025, and Evercrisp entered a jointly administered Chapter 11 case in 2026.

- **Founded:** 2021
- **Headquarters:** South San Francisco, United States
- **Founders:** Jennifer Doudna (Scientific co-founder), Tanja Kortemme (Scientific co-founder and board member), Spiros Liras (Co-founder and board member)
- **Products:** Miniprotein delivery platform, Oligonucleotide delivery, Self-delivering genome editors
- **Notable:** Two preclinical presentations at ASGCT 2025., Investor report cited a nephrin-binding miniprotein with more than sixfold stronger binding than a prior best binder., Co-applicant on a CRISPR-Cas effector patent application.

## Products & services

- **Miniprotein delivery platform** — Machine-learning engineered proteins designed to bind selected cell receptors and deliver therapeutic payloads. Preclinical.
- **Oligonucleotide delivery** — Miniprotein conjugates intended to improve targeted ASO and siRNA uptake. Preclinical.
- **Self-delivering genome editors** — CRISPR/Cas ribonucleoprotein delivery concept using miniproteins and endosomal escape elements. Preclinical.

## Achievements

- Two preclinical presentations at ASGCT 2025.
- Investor report cited a nephrin-binding miniprotein with more than sixfold stronger binding than a prior best binder.
- Co-applicant on a CRISPR-Cas effector patent application.

## Latest updates

- **2026-08** — Filing targeted in vivo biodistribution and muscle functional data by Q4 2026; results were not yet reported.
- **2026-02** — Filing laid out vendor studies needed to restart research.
- **2026-01** — Evercrisp entered a jointly administered Chapter 11 case and received an order authorizing portfolio funding.
- **2025-05** — Presented two preclinical programs at ASGCT.

## Links

- Website: https://www.evercrispbio.com/
- LinkedIn: https://www.linkedin.com/company/evercrisp-biosciences/

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Profile page: https://yespress.io/evercrisp-biosciences
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Last updated: 2026-09-30