# Deep Principle

> Deep Principle is an AI-for-Science company spun out of MIT that builds ReactiveAI, a closed-loop R&D platform fusing generative AI, quantum chemistry, and high-throughput experimentation to discover new materials, catalysts, and chemical processes far faster and cheaper than traditional trial-and-error labs. Founded by MIT PhDs Haojun Jia and Chenru Duan, the company targets materials, energy, and pharmaceutical R&D and has reported quantum-chemistry speedups on the order of 20,000x versus conventional DFT.

- **Founded:** 2024
- **Headquarters:** Cambridge, Massachusetts, United States
- **Founders:** Haojun Jia (Co-Founder & CEO), Chenru Duan (Co-Founder & CTO)
- **Team size:** ~15 employees
- **Products:** ReactiveAI, ECML Framework, SciClaw, AQCat25 dataset, SAGA
- **Notable:** Reported ~20,000x speedup over traditional DFT while maintaining accuracy., Raised 100 million yuan Pre-A funding backed by Lenovo- and Baidu-affiliated funds (March 2025)., Recruited MIT professor Heather J. Kulik as Chief Scientist (March 2026).

## Products & services

- **ReactiveAI** — Proprietary R&D platform merging generative AI, quantum simulations, and high-throughput experimental systems. Built on five in-house algorithm modules covering reaction generation, accurate computation, large-scale screening, experiment acceleration, and synthetic planning - forming a closed loop across discovery, property prediction, formulation optimization, and experimental validation.
- **ECML Framework** — An orchestration framework that coordinates Experiment, Compute, and Machine Learning through AI decision-making, automating the scientific loop.
- **SciClaw** — An 'AI Research Partner' product launched in 2026, designed to assist scientists in research workflows.
- **AQCat25 dataset** — A quantum-chemistry dataset spanning a broader chemical space, including transition states and spin polarization, aimed at catalysis applications.
- **SAGA** — A generalist AI agent demonstrated on inorganic materials design and chemical process design across chemistry, biology, and materials science.

## Achievements

- Reported ~20,000x speedup over traditional DFT while maintaining accuracy.
- Raised 100 million yuan Pre-A funding backed by Lenovo- and Baidu-affiliated funds (March 2025).
- Recruited MIT professor Heather J. Kulik as Chief Scientist (March 2026).
- Both founders recognized on Forbes China lists (Duan: Forbes China 100 Elite Returnees and 30 Under 30).
- Published research in JACS and Nature Machine Intelligence, including optimal transport for generating chemical-reaction transition states.
- Co-authored a multi-university framework evaluating top LLMs on scientific discovery.

## Latest updates

- **2026-04** — Launched SciClaw, an AI Research Partner, and attended CHINAPLAS 2026.
- **2026-03** — Appointed MIT professor Heather J. Kulik as Chief Scientist.
- **2025-03** — Announced 100 million yuan Pre-A funding round backed by Lenovo and Baidu funds.

## Links

- Website: https://deepprinciple.com
- LinkedIn: https://www.linkedin.com/company/deep-principle
- Twitter/X: https://x.com/DeepPrinciple

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Profile page: https://yespress.io/deep-principle
Published by YesPress — https://yespress.io
Last updated: 2026-06-09