# Cyagen Biosciences

> Cyagen Biosciences is a life-sciences contract research organization that builds custom genetically engineered rodent models - knockout, knockin, conditional, and humanized mice and rats - for academic labs and drug developers. Founded in 2006 and headquartered in Santa Clara, California, with major operations in China, Japan, and Europe, Cyagen has grown into one of the world's largest suppliers of custom mouse and rat models, complemented by stem-cell products and a fast-growing gene-delivery arm, VectorBuilder, that designs and manufactures viral vectors from research through clinical CDMO work.

- **Founded:** 2006
- **Headquarters:** Santa Clara, California, United States
- **Founders:** Lance Han (Founder & Chief Innovation Officer (also cited as Chairman))
- **Team size:** ~900 employees
- **Products:** Custom Mouse & Rat Models, TurboKnockout, HUGO-GT (Humanized Genomic Ortholog for Gene Therapy), Catalog Model Bank, Stem Cell Products
- **Notable:** One of the world's largest providers of custom-engineered mouse and rat models, Models cited in 10,000+ published research papers, 18,000+ validated mouse strains across 20+ research areas

## Products & services

- **Custom Mouse & Rat Models** — Made-to-order knockout, knockin, conditional knockout, transgenic and humanized rodent models for disease research.
- **TurboKnockout** — Proprietary gene-targeting technology that reduces breeding by two generations, delivering conditional knockout, reporter knockin and humanized models in as fast as 4-8 months.
- **HUGO-GT (Humanized Genomic Ortholog for Gene Therapy)** — Full-length in-situ replacement of mouse genes with human counterparts to test ASO, CRISPR and siRNA gene-therapy candidates.
- **Catalog Model Bank** — 18,000+ validated, ready-to-ship mouse strains across 20+ research areas including oncology, neurology and metabolism.
- **Stem Cell Products** — Cell lines, culture media, and differentiation kits for regenerative-medicine and disease research.
- **VectorBuilder** — Online platform and CDMO for designing and manufacturing viral vectors (AAV, lentivirus) from research to clinical scale.
- **CRO Services for Cell & Gene Therapy** — Viral vector development, CAR design and construction, disease models, phenotyping, and pharmacodynamic evaluation.

## Achievements

- One of the world's largest providers of custom-engineered mouse and rat models
- Models cited in 10,000+ published research papers
- 18,000+ validated mouse strains across 20+ research areas
- Closed a $41M Series B to expand its animal-model business (2020)
- VectorBuilder produced tens of thousands of custom AAV vectors worldwide
- VectorBuilder won two IMAPAC gene-therapy and CDMO excellence awards (2025) plus a BioTech Breakthrough award (2024)
- AAALAC-accredited facilities totaling 40,000+ square meters

## Latest updates

- **2025-10** — VectorBuilder unveiled miniVec, a next-generation plasmid system that eliminates antibiotic-resistance genes to improve safety, yield and cost.
- **2025-05** — VectorBuilder won IMAPAC's Asia-Pacific Cell & Gene Therapy and Biologics CDMO excellence awards; also received a CDMO Leadership Award.
- **2025-01** — VectorBuilder partner Ucello received FDA IND approval for its UC101 CAR-T therapy with Cyagen/VectorBuilder CDMO support.
- **2024-11** — VectorBuilder earned a Bio-Industrial Innovation of the Year Award from BioTech Breakthrough.

## Links

- Website: https://cyagen.com
- LinkedIn: https://www.linkedin.com/company/cyagen-biosciences
- Twitter/X: https://twitter.com/cyagenbio
- Facebook: https://facebook.com/CyagenBiosciences

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Profile page: https://yespress.io/cyagen
Published by YesPress — https://yespress.io
Last updated: 2026-07-12