# Cultivation Capital

> Cultivation Capital is a St. Louis-based early-stage venture firm that manages a family of specialist funds spanning software and IT, life sciences and health technology, agriculture and food technology, geospatial technology, and Midwest seed investing. It usually enters at Seed or Series A, writes initial checks from $100,000 to $3.5 million, and pairs capital with board-level operating help and a regional-to-global network.

- **Founded:** 2012
- **Headquarters:** St. Louis, United States
- **Founders:** Cliff Holekamp (Cofounder, Managing Director and General Partner), Brian Matthews (Cofounder and General Partner), Kyle Welborn (Cofounder and General Partner)
- **Team size:** A 2026 regulatory-data profile reports 18 employees; the firm's website separately lists a broader roster of general partners, principals, counsel and venture advisers.
- **Products:** Life Sciences & Health Technology strategy, Software & Information Technology strategy, Agriculture & Food Technology strategy, Midwest Seed Stage strategy, Geospatial Technology strategy
- **Notable:** Backed more than 120 startups since 2012, according to the firm's careers page., Invested across more than 25 states or countries., Completed more than 60 follow-on investments.

## Products & services

- **Life Sciences & Health Technology strategy** — Post-seed and pre-Series A investing in therapeutics, diagnostics, research tools, medical devices and healthcare IT, with initial investments generally from $250,000 to $1 million.
- **Software & Information Technology strategy** — Pre-Series A investment in early-stage technology companies with product, revenue and traction; typical investments range from $500,000 to $3 million plus follow-on capacity.
- **Agriculture & Food Technology strategy** — Investing alongside the Yield Lab in crops, animal health, precision agriculture, sustainability, logistics and food ingredients; initial checks generally range from $100,000 to $1.5 million.
- **Midwest Seed Stage strategy** — The Spirit of St. Louis Fund collaboration with Twain Financial Partners backs Midwest fintech, healthcare and agtech companies, typically starting around $250,000.
- **Geospatial Technology strategy** — Worldwide early-stage investment in companies using location intelligence, generally with $500,000 to $2 million initial checks and follow-on capacity.
- **Portfolio support** — Board service, operating counsel, customer and collaborator introductions, hiring visibility and connections to later-stage investors.

## Achievements

- Backed more than 120 startups since 2012, according to the firm's careers page.
- Invested across more than 25 states or countries.
- Completed more than 60 follow-on investments.
- Leads roughly half of the investment rounds in which it participates.
- Ranked by Crunchbase News among active younger U.S. venture investors in 2019.
- Built an exit record that includes portfolio outcomes involving Bayer, Snap, Boston Scientific, NielsenIQ, Ansys, Vista Equity Partners and realtor.com.
- Cultivation Capital Seed Fund III received an SBIC license in July 2024.
- Cultivation Capital, LLC became an SEC-registered investment adviser effective May 12, 2026.

## Latest updates

- **2026-07** — Portfolio company ReturnLogic was acquired by Redo.
- **2026-07** — Portfolio company Hydrosat received a NASA commercial satellite data contract under a multi-award program.
- **2026-06** — Portfolio company Capacity reported surpassing $100 million in annual recurring revenue and serving more than 20,000 organizations.
- **2026-05** — Cultivation Capital, LLC's SEC investment-adviser registration became effective.
- **2026-03** — Portfolio company Corstasis Therapeutics entered an agreement to be acquired by Esperion.
- **2026-02** — BemAgro announced a $5.8 million round led by Yield Lab LATAM for its agricultural geospatial-intelligence platform.
- **2025-04** — Cultivation Capital Life Sciences Fund IV filed a Form D notice with the SEC.

## Links

- Website: https://cultivationcapital.com
- LinkedIn: https://www.linkedin.com/company/cultivation-capital
- Twitter/X: https://twitter.com/CultivationCap
- Facebook: https://www.facebook.com/CultivationCapital

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Profile page: https://yespress.io/cultivation-capital
Published by YesPress — https://yespress.io
Last updated: 2026-08-17